Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility
نویسندگان
چکیده
منابع مشابه
The Impact of Letrozole Versus Clomiphene Citrate on Uterine Blood Flow in Patients with Unexplained Infertility
OBJECTIVE To compare the effectiveness of letrozole and clomiphene citrate (CC) on uterine blood flow rate in patients with unexplained infertility. MATERIALS AND METHODS In this randomized clinical trial 90 women with unexplained infertility referred to a university clinic from January 2011- December 2013 were enrolled. Thirty patients were randomized for letrozole, 30 patients for CC and 3o...
متن کاملLetrozole versus clomiphene for infertility in the polycystic ovary syndrome.
BACKGROUND Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome, but aromatase inhibitors, including letrozole, might result in better pregnancy outcomes. METHODS In this double-blind, multicenter trial, we randomly assigned 750 women, in a 1:1 ratio, to receive letrozole or clomiphene for up to five treatment cycles, with visits to determine ...
متن کاملCongenital Malformations among Babies Born Following Letrozole or Clomiphene for Infertility Treatment
CONTEXT Clomiphene citrate (CC) is the first line drug for ovulation induction but because of its peripheral antiestrogenic effect, letrozole was introduced as the 2nd line drug. It lacks the peripheral antiestrogenic effect and is associated with similar or even higher pregnancy rates. Since letrozole is a drug for breast cancer, its use for the purpose of ovulation induction became controvers...
متن کاملMinimal Stimulation Using Gonadotropin Combined with Clomiphene Citrate or Letrozole for Intrauterine Insemination
PURPOSE To evaluate the efficacy of minimal stimulation using discretely administered gonadotropin combined with clomiphene citrate (CC) or letrozole (LTZ) for intrauterine insemination (IUI) cycles. MATERIALS AND METHODS Total 257 IUI cycles from 158 infertile couples were assessed. A CC dose of 100 mg/day (n=126 cycles) or a LTZ dose of 5 mg/day (n=131 cycles) was administered on days 3-5 o...
متن کاملLetrozole versus Clomiphene Citrate in Patients with Anovulatory Infertility
Objective: To compare the effectiveness of letrozole and clomiphene citrate (CC) in patients with anovulatory infertility. Design: Open, prospective, randomized, parallel group, multicentric, comparative trial. Setting: Outpatient clinics of infertility centers in India. Patient(s): Fifty-five patients with anovulatory infertility were recruited. Twenty-seven patients (59 cycles) were given let...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2015
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1414827